Status:
COMPLETED
Impact of Full Correction of PTA in Renal Transplant Recipients
Lead Sponsor:
Hamid Al-Essa Organ Transplant Center
Conditions:
Anemia
Phase:
NA
Brief Summary
Background: Post-transplant anemia (PTA) might be associated cardiovascular morbidity and even increased mortality. Objectives: We aimed to assess the impact of full correction of chronic PTA on car...
Detailed Description
Two hundred and eighty anemic renal transplant recipients with stable graft function- who are followed up in Hamed Al-Essa organ transplant centre - will be assessed for the possible causes of their a...
Eligibility Criteria
Inclusion
- Patients who fulfilled the following criteria were included in the study:
- Adult renal transplant patients (≥21years),
- Informed consent,
- Stable maintenance subcutaneous ESA therapy with constant dose interval during the last 2 months,
- Haemoglobin (Hb) ≥10mg/dL (Hct 32%),
- Transferrin saturation (TSAT) ≥20% (during the screening phase),
- and serum ferritin ≥100 ng/mL
Exclusion
- We excluded patients with the following criteria:
- Acute or chronic bleeding, or erythrocyte transfusion, within the preceding 8 weeks. change in Hb level ≥ 2 g/dL during screening phase,
- Hemolytic anemia,
- Recent infection or rejection,
- Diastolic blood pressure \>100mmHg or discontinuation of ESA due to hypertension in the 6 months prior to study,
- Vitamin B12 or folic acid deficiency,
- Uncontrolled or secondary hyperparathyroidism,
- Acute or chronic systemic inflammatory disease and/or C-reactive protein (CRP) \>30 mg/L,
- Hemodialysis due to failure of a kidney transplant,
- and malignancy
Key Trial Info
Start Date :
January 20 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 20 2018
Estimated Enrollment :
280 Patients enrolled
Trial Details
Trial ID
NCT03861637
Start Date
January 20 2015
End Date
December 20 2018
Last Update
March 4 2019
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