Status:
TERMINATED
Reliability of Paired Associative Stimulation-induced Neuroplasticity After Stroke
Lead Sponsor:
Burke Medical Research Institute
Conditions:
Stroke
Eligibility:
All Genders
19+ years
Phase:
NA
Brief Summary
Paired associative stimulation (PAS) is a non-invasive stimulation method which is known to modulate corticospinal excitability through mechanisms related to long-term potentiation and long-term depre...
Detailed Description
One of the assumptions in stroke rehabilitation is that motor training will lead to motor re-learning and persistent improvements through mechanisms involving neuroplasticity, defined as the ability o...
Eligibility Criteria
Inclusion
- Unilateral ischemic stroke with residual arm weakness (Fugl-Meyer Upper Limb \< 60) more than 6 months prior to enrollment.
- Ability to give informed consent and understand the tasks involved.
- Age over 18 years.
Exclusion
- Hemorrhagic Stroke
- Contraindications to TMS: history of seizure/epilepsy, pacemaker, other neurological disorders, brain surgery, metal implant/fragment in the head, pregnancy
- Taking medications or substances that are known to affect PAS-induced plasticity within the past 2 months: selective serotonin reuptake inhibitors, dopamine, dopamine agonists, haloperidol, lithium, acetylcholinesterase inhibitors, beta-blockers, nimodipine, levetiracetam, ethosuximide, benzodiazepines, baclofen, nicotine
- Peripheral neuropathy or history of nerve injury in the paretic upper limb.
- Social and/or personal circumstances that interfere with ability to return for all study visits.
Key Trial Info
Start Date :
April 17 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 12 2022
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT03861806
Start Date
April 17 2019
End Date
September 12 2022
Last Update
November 21 2022
Active Locations (1)
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1
Burke Neurological Institute
White Plains, New York, United States, 10605