Status:
UNKNOWN
Metronidazole vs Azithromycin in Periodontal Surgery for Patients Positive to Porphyromonas Gingivalis
Lead Sponsor:
Universidad Complutense de Madrid
Conditions:
Periodontitis
Surgery
Eligibility:
All Genders
Phase:
NA
Brief Summary
The objective of this study is to determine whether, in patients with non treated periodontitis (stage III and IV) positive to Porphyromonas gingivalis, the use of systemic antimicrobials (metronidazo...
Detailed Description
Design: randomized, parallel and triple blind clinical trial Sample: Patients with periodontitis (stages III and IV) and positive to Porphyromonas gingivalis who potentially need periodontal surgery ...
Eligibility Criteria
Inclusion
- Diagnosis of periodontitis (stages III or IV) that may require periodontal surgery
- Have at least 10 teeth in function, excluding third molars.
- Present locations with probing depth (PS)\> 6 mm in at least 30% of the teeth.
- Present radiographic evidence of moderate-severe bone loss in at least 30% of the dentition.
- Detection of P. gingivalis in subgingival samples taken at the screening visit as well as in the post-scaling and root planning visit and processed by culture.
- Systemically healthy patients.
Exclusion
- Pregnant or lactating women.
- Presenting systemic pathology and / or taking medication that may affect the periodontal situation and / or patients requiring antibiotic prophylaxis.
- Have received systemic antimicrobial treatment in the previous 6 months.
- Have received periodontal treatment in the 6 months prior to the beginning of the study.
- Patients allergic to metronidazole, or to any of the components of commercial formulations thereof (Flagyl®).
- Patients allergic to azithromycin, or to any of the components of commercial formulations thereof (Zithromax®).
- Patients who refuse to sign the informed consent.
Key Trial Info
Start Date :
January 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2019
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03862456
Start Date
January 1 2013
End Date
July 1 2019
Last Update
March 5 2019
Active Locations (1)
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1
Faculty of Dentistry, Univesity Complutense, Madrid
Madrid, Spain, 28040