Status:
COMPLETED
Effects of Acute Prucalopride Administration in Healthy Volunteers
Lead Sponsor:
University of Oxford
Conditions:
Molecular Mechanisms of Pharmacological Action
Depression
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
This study will investigate whether administration of a single dose of the serotonin receptor subtype 4 (5-HT4) partial agonist prucalopride has effects on emotional processing and non-emotional cogni...
Eligibility Criteria
Inclusion
- Male or female
- Aged 18-40 years
- Willing and able to give informed consent for participation in the study
- Sufficiently fluent English to understand and complete the task
Exclusion
- Current usage of psychoactive medication (except the contraceptive pill, the Depo-Provera injection or the progesterone implant)
- Any past or current Axis 1 DSM-IV psychiatric disorder
- Significant medical condition
- Current or past gastro-intestinal disorder or irritable bowel syndrome
- Current pregnancy or breastfeeding
- Known lactate deficiency or any other problem absorbing lactose, galactose or glucose
- Current or past history of drug or alcohol dependency
- Participation in a psychological or medical study involving the use of medication within the last 3 months
- Previous participation in a study using the same, or similar, emotional processing tasks
- Smoker \> 5 cigarettes per day
- Typically drinks \> 6 caffeinated drinks per day
Key Trial Info
Start Date :
February 7 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 8 2017
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT03863366
Start Date
February 7 2017
End Date
August 8 2017
Last Update
March 5 2019
Active Locations (1)
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1
University of Oxford
Oxford, United Kingdom, OX3 7JX