Status:
UNKNOWN
The Influence of Overfeeding Different Macronutrients on Whole-body Insulin Sensitivity
Lead Sponsor:
Loughborough University
Conditions:
Insulin Resistance
Type 2 Diabetes
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
This study will investigate the effect of high-carbohydrate vs. high-fat overfeeding (130% of energy requirements) on whole body insulin sensitivity. Following habitual diet, participants will be ran...
Eligibility Criteria
Inclusion
- 18-40 years
- BMI = 18.5-29.9 kg/m2
- Male or female
- Physically active (\> 3 x 30 min moderate exercise per week)
- Non-smoker (including the use of vaporisers and e-cigarettes)
- Healthy (determined by the School's standard health questionnaire)
- No cardiometabolic or inflammatory illness
Exclusion
- Outside of age-range
- Outside BMI range
- Inactive (\< 3 x 30 min moderate exercise per week)
- Smoker
- Taking medication
- History of cardiometabolic or inflammatory illness
- Vegetarian/ vegan (as the high-fat diet is based on animal fats)
- Other dietary restrictions which prevent consumption of the experimental diet
- Consumption of probiotics within last 3 months (these influence the gut microbiota)
- Participation in another clinical trial
- Those with known or suspected food intolerances, allergies or hypersensitivity
- Women who are known to be pregnant or who are intending to become pregnant over the course of the study
Key Trial Info
Start Date :
May 22 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2021
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03863431
Start Date
May 22 2019
End Date
June 1 2021
Last Update
February 24 2021
Active Locations (1)
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1
School of Sport, Exercise and Health Sciences
Loughborough, Leicestershire, United Kingdom, LE11 3TU