Status:
COMPLETED
Influence of Dopaminergic Blockade on Stress Responses, Motivation and Emotional Reactivity in Humans.
Lead Sponsor:
Philipps University Marburg
Collaborating Sponsors:
University of Hamburg-Eppendorf
Conditions:
Healthy Participants
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
The study aims to identify whether partial blockade of human dopamine signaling with antipsychotic drugs affects human stress responses, motivation and emotion. 84 healthy adult participants are plann...
Detailed Description
The study is a double blind, placebo controlled, randomized trial with two groups. One group will be receiving placebo (PG) and the other group will receive 300 mg amisulpride (VG). All participants a...
Eligibility Criteria
Inclusion
- Common European Framework of Reference for Languages level B2 in German language.
- Consent ability for all relevant aspects of the experiment.
Exclusion
- Amisulpride allergy.
- Allergy to other components of amisulpride / placebo capsules like lactose.
- Daily intake of other medication including contraceptives.
- Tendency to seizures.
- Diagnosis of cancer especially pheochromocytoma, prolactinoma, or breast cancer.
- Kidney dysfunction: creatinine clearance below 10 ml per minute.
- High risk for stroke or thrombosis.
- Known prolongation of the QT interval,
- Any substantial medical condition that is capable of reducing the volunteers ability to participate at the study.
- Suicidal thoughts or suicide attempts in the past or at present.
- Substantial mental disorders especially schizophrenia, bipolar disorder, drug abuse, or personality disorders.
- Pregnancy or breastfeeding.
Key Trial Info
Start Date :
April 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 15 2020
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT03863691
Start Date
April 15 2019
End Date
July 15 2020
Last Update
September 21 2020
Active Locations (1)
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1
Clinical Psychology and Psychotherapy, Gutenbergstr. 18
Marburg, Hesse, Germany, 35037