Status:
COMPLETED
Gastric Emptying - Implications for the Pathogenesis of Type 2 Diabetes
Lead Sponsor:
University of Nottingham
Collaborating Sponsors:
University of Adelaide
Conditions:
Diabetes Mellitus, Type 2
Eligibility:
All Genders
18-60 years
Brief Summary
People of black African and Caribbean descent have a greater risk of developing type 2 diabetes than white Europeans. The aim of this study is to increase our knowledge of how the condition may arise,...
Detailed Description
Background It is recognized that there are differences between ethnic groups in the risk of developing type 2 diabetes (T2D), but the underlying pathophysiology remains poorly defined. For example, wh...
Eligibility Criteria
Inclusion
- White European or black African / Caribbean heritage
- BMI \>18 kg/m2
- Ability to give written informed consent
- English speaking
Exclusion
- Any significant medical condition
- Uncontrolled hypertension
- Alcohol consumption \>14 units / week
- Random blood Glucose concentration above 7.8mmol/l
- Hemoglobin A1c (HbA1c) \>47mmol/mol (\>6.4%)
- Use of regular medication, (oral contraceptive pill or antihypertensive medication are acceptable if use has been for \>6 months)
- History of Irritable Bowel Syndrome, food intolerances or any gastrointestinal disorders
- Previous bariatric surgery, or gastrointestinal surgery which may affect normal function (e.g. bowel resection)
Key Trial Info
Start Date :
March 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 31 2023
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT03864562
Start Date
March 1 2019
End Date
March 31 2023
Last Update
December 4 2025
Active Locations (1)
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1
David Greenfield Human Physiology Unit, University of Nottingham
Nottingham, Notts, United Kingdom, NG72UH