Status:
UNKNOWN
Therapy With High-flow Oxygen by Nasal Cannula vs Noninvasive Ventilation in Patients With Acute Hypoxemic Respiratory Failure: a Crossover Physiologic Study
Lead Sponsor:
University Health Network, Toronto
Conditions:
Hypoxemia
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
Background and rationale: A large multicenter randomized controlled trial demonstrated that in patients with hypoxemic non-hypercapnic respiratory failure treatment with nasal high flow oxygen (NHF) r...
Eligibility Criteria
Inclusion
- Hypoxemia defined by a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen (PaO2:FiO2) ≤ 300 while the patient is breathing oxygen through NHF for at least 15 minutes;
- Respiratory rate \> 25 breaths/minute;
- Partial pressure of arterial carbon dioxide (PaCO2) ≤ 45 mmHg;
- Absence of clinical history of underlying chronic respiratory failure.
Exclusion
- Lack of consent;
- Age \< 18 years;
- Invasive mechanical ventilation for \> 48 hours in the same hospital admission
- Immediate need for intubation;
- Previous inclusion in the present study;
- Systolic arterial pressure \< 90 mmHg after optimal fluid therapy;
- Cardiogenic pulmonary edema;
- Glasgow Coma Scale \< 12;
- Imminent death;
- Contraindications to noninvasive ventilation;
- Tracheostomy.
Key Trial Info
Start Date :
March 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 15 2021
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03865056
Start Date
March 15 2019
End Date
March 15 2021
Last Update
March 6 2019
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