Status:
COMPLETED
Forearm Immobilization, Metabolic Health, and Muscle Loss
Lead Sponsor:
University of Exeter
Collaborating Sponsors:
Wellcome Trust
Conditions:
Healthy
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
The present study will investigate the impact of altered substrate availability on muscle atrophy, insulin sensitivity and muscle protein synthesis following short-term forearm immobilization
Detailed Description
Thirty-six healthy young volunteers will undergo 2 days of forearm immobilization combined with ingestion of one of two drug or placebo. Before and after immobilization, they will receive a stable iso...
Eligibility Criteria
Inclusion
- Males and females 18-40 years of age
- Body mass index between 18 and 27
Exclusion
- Any diagnosed metabolic impairment (e.g. type 1 or 2 diabetes)
- Any diagnosed cardiovascular disease
- Hypertension (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
- Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
- Regular use of nutritional supplements
- Metallic implants
- A personal or family history of thrombosis, epilepsy, seizures or schizophrenia
- Any previous motor disorders
- Any known disorders in lipid metabolism
- Any known disorders in muscle metabolism
- Known allergy for Acipimox, beta agonist, or other substances in the tablets
- Known sensitivity for sympathomimetic drugs
- Known hypokalaemia
- Presence of an ulcer in the stomach or gut and/or strong history of indigestion
- Known severe kidney problems
- Pregnancy
- Unable to give consent
Key Trial Info
Start Date :
May 10 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2021
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT03866512
Start Date
May 10 2019
End Date
July 1 2021
Last Update
June 21 2024
Active Locations (1)
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1
Royal Exeter & Devon NHS Foundation Trust
Exeter, Devon, United Kingdom