Status:
TERMINATED
Epigenetic and Metabolomic Changes in Childhood Cancer Survivors
Lead Sponsor:
Wake Forest University Health Sciences
Conditions:
Childhood Cancer
Eligibility:
All Genders
1-18 years
Brief Summary
The purpose of this research study is to try and identify markers in childhood cancer survivors to help predict if they will develop late effects from their cancer treatment.
Detailed Description
This is a pilot study to obtain preliminary data that will be used to apply for a larger grant to fund the full study with an adequate sample size for analysis. Specific Aim 1. What are the epigeneti...
Eligibility Criteria
Inclusion
- Childhood cancer survivors age 1-18 years old who received intensive treatment which included anthracycline and/or alkylating agent chemotherapy.
- Diseases which will be eligible include, high risk or very high risk acute lymphoblastic leukemia, acute myeloid leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, sarcomas.
- Healthy controls:
- • Healthy controls are defined as children ages 1-18 years old who are free from diseases or medical conditions that might be affected by or have an impact on this research study. Healthy controls will be matched with patients for age, sex, ethnicity, geographic region, and tanner stage, since it is known that these factors can affect the epigenetic signature of an individual. Controls will already be having blood drawn as part of their routine care.
Exclusion
- Cancer survivors:
- • Patients who have received a bone marrow transplant will not be eligible.
- Healthy controls:
- • Age, sex, ethnicity, geographic region, and tanner stage matched controls with any acute or chronic disease will be excluded.
Key Trial Info
Start Date :
February 25 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 16 2020
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT03866707
Start Date
February 25 2019
End Date
May 16 2020
Last Update
December 20 2023
Active Locations (1)
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1
Comprehensive Cancer Center of Wake Forest University
Winston-Salem, North Carolina, United States, 27157