Status:
COMPLETED
Magnetic Resonance Imaging for Detection of Peritoneal Mesothelioma
Lead Sponsor:
University of Chicago
Conditions:
Mesothelioma
Peritoneal Mesothelioma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
For cancers, such as mesothelioma, that spread to the lining of the stomach, detecting the cancer is very difficult with CT or MRI scans. Researchers at the University of Chicago want to find out if t...
Eligibility Criteria
Inclusion
- 18 years old or older
- Biopsy-proven MPM
- Surgery for PM planned at UCM within 60 days
- Able to tolerate CT, MRI, US scans, and surgery
- Able to provide written informed consent
- For women of child bearing age, ability and willingness to use appropriate contraceptive methods before imaging and for a period of 365 days thereafter.
Exclusion
- Pregnancy / Breastfeeding
- Allergy or intolerance to iodinated or gadolinum contrast dyes
- Contraindications to CT or MRI imaging including chronic kidney disease with GFR \<60mL/min/1.73m2
- Bioimplants unsuitable for MRI imaging (activated by mechanical, electronic, radiofrequency, or magnetic means), such as cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps
- Permanent tattoos or eyeliner with magnetic dyes
- Subjects with shrapnel or metal fragments lodged in the body
- Anxiety, claustrophobia, or any medical condition that would preclude lying still in an MRI scanner for 1-1.5 hours
- Cardiac, circulatory, or perspiration problems leading to impaired thermoregulation
- Respiratory or cardiac impairment limiting the ability to lie flat
- Inability to breath-hold for MRI acquisition
- Vascular or aneurysm clips or any other surgical implant that is not MRI-compatible
- Any other ferromagnetic bioimplant that would be damaged by MRI
- Mental, cognitive, or mental health impairments that preclude the subject from providing informed consent or adhering to the treatment protocol
- Subjects unable to adhere to the protocol or communicate effectively with researchers
- Imprisoned subjects
- Subjects with history of prior CRS/HIPEC or other peritonectomy surgery that might alter characteristics of the peritoneum
Key Trial Info
Start Date :
October 10 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 20 2022
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT03867578
Start Date
October 10 2018
End Date
July 20 2022
Last Update
July 31 2024
Active Locations (1)
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1
University Of Chicago Medicine Comprehensive Cancer Center
Chicago, Illinois, United States, 60637