Status:
COMPLETED
Comparison of Carvedilol and Atorvastatin for Preventing of Contrast-Induced Nephropathy.
Lead Sponsor:
rabab ahmed mohamed
Collaborating Sponsors:
Cairo University
Conditions:
Contrast-induced Nephropathy
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
This prospective study is intended to evaluate if carvedilol has any potential protective effect over atorvastatin on the development of contrast-induced nephropathy (CIN) following cardiac catheteriz...
Detailed Description
This study enrolled 150 patients planned for CC, and randomly assigned for one of the three groups. Group (A)include 49 patients who received two atorvastatin dose 80 mg 12 hours before CC and 40 mg j...
Eligibility Criteria
Inclusion
- Patients aged between 18 and 70 years.
- Serum creatinine ≤ 1.5 mg/dL.
- Using a moderate dose of atorvastatin (40 mg or equivalent dose of other statins).
- Moderate to high-risk for CIN.
Exclusion
- Patients suffering from ST-segment elevation myocardial infarction (STEMI)
- Patients need for immediate cardiac catheterization
- Elevated liver enzymes (Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) three times the upper limit of normal).
- Active infection.
- Any contraindication to carvedilol, or atorvastatin.
- Patients on regular use of vitamins, minerals.
- Using medication with antioxidant properties e.g., beta-carotene, vitamin E, vitamin C, selenium, theophylline or N-acetyl cysteine 7 days prior to CC.
- Hemodynamically unstable patients (defined as abnormal or unstable blood pressure, especially hypotension (blood pressure less than 90/60 mm Hg).
- Patients who required dialysis.
- Pregnancy.
- Using of carvedilol in the past three months.
- Using a nephrotoxic agent in the past 48 hours or exposure to a contrast agent in the past 7 days prior to cardiac catheterization.
Key Trial Info
Start Date :
February 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 15 2017
Estimated Enrollment :
144 Patients enrolled
Trial Details
Trial ID
NCT03867994
Start Date
February 1 2016
End Date
May 15 2017
Last Update
March 12 2019
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