Status:
COMPLETED
Validation of a Semi-automatized Method to Detect Cyclic Hyperinflation on CT-scan in ARDS
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Acute Respiratory Distress Syndrome (ARDS)
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study aims to validate a semi-automatized method to quantify cyclic hyperinflation on CT-scan of ARDS patients. The gold standard will be cyclic hyperinflation assessed on the same CT scan, usin...
Eligibility Criteria
Inclusion
- ARDS patients defined by the Berlin definition
- invasive mechanical ventilation with an arterial oxygen pressure (PaO2)/inspired fraction of oxygen (FiO2) ratio ≤ 200 mm Hg
- Indication of CT scan identified by the clinician in charge
- oesophageal catheter already inserted
Exclusion
- requirement of contrast agent for a chest CT-scan
- ARDS criteria present for more than 72 hours
- Chronic Obstructive Pulmonary Disease (COPD) on a previous lung function test
- pneumothorax or bronchopleural fistula
- patient without both sedation and neuromuscular blocking agents
- contra-indication to transport to the imaging facility
- treatment with extracorporeal membrane oxygenation or extracorporeal carbon dioxide (CO2) removal
- Latex or curare allergy
- patient previously included in the study
- pregnancy
- patient under limitation of care
- patient under an exclusion period following inclusion in another clinical trial
- patient under a legal protective measure
- patient unaffiliated with social security
- inform consent not obtained by next of kin
Key Trial Info
Start Date :
May 21 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 16 2021
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT03870009
Start Date
May 21 2019
End Date
February 16 2021
Last Update
August 22 2025
Active Locations (1)
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1
Croix Rousse Hospital
Lyon, France, 69004