Status:
COMPLETED
Emotion Study/Substudy: Flexible Brain Study
Lead Sponsor:
University of Florida
Collaborating Sponsors:
National Institute on Aging (NIA)
Florida Department of Health
Conditions:
Aging
Emotions
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
The proposed research applies the highly innovative technology of real-time functional Magnetic Resonance Imaging (rtfMRI) to examine plasticity of brain-regulatory mechanisms related to cognitive and...
Detailed Description
There is increasing evidence that age-related alterations in brain function associated with affective processing and attention contribute to these motivational and emotional changes with age. Based o...
Eligibility Criteria
Inclusion
- Young adults
- aged 18-35 years of age
- native English speaker
- at least 8th grade education
- generally physically and neurologically healthy as determined by the Health Demographics Screener
- eligible for MRI as determined by the MRI Eligibility Interview (including not being pregnant)
- scores within normal limits on a cognitive screener (MoCA)
- no indication of serious psychiatric disturbance including major depression (based on Mental Health Screener)
- willing and able to give informed consent
- Older adults
- age 55-100 years of age
- native English speaker
- at least 8th grade education
- generally physically and neurologically healthy as determined by the Health Demographics Screener
- eligible for MRI as determined by the MRI Eligibility Interview
- no indication of dementia based on score of 30 or above on the Telephone Interview for Cognitive Status and nonimpaired score on the Montreal Cognitive Assessment (MoCA -- score of 22 and above)
- no indication of serious psychiatric disturbance including current major depression (based on Mental Health Screener)
- willing and able to give informed consent
- Parkinson patients
- must meet criteria for diagnosis of idiopathic Parkinson disease according the UK Brain Bank by a movement trained neurologist.
- age 55-100 years of age
- native English speaker
- at least 8th grade education
- generally physically and neurologically healthy other than Parkinson disease
- eligible for MRI as determined by the MRI Eligibility Interview
- no indication of dementia based on cognitive screening measures (TICS -- score of 30 or above, and MoCa -- score of 22 and above)
- no indication of serious psychiatric disturbance including current major depression
- willing and able to give informed consent
- Individuals with SCD and a family history of dementia or Alzheimer's disease
- age 55-100 years of age
- native English speaker
- at least 8th grade education
- generally physically and neurologically healthy as determined by the Health Demographics Screener
- eligible for MRI as determined by the MRI Eligibility Interview
- no indication of dementia based on score of 30 or above on the Telephone Interview for Cognitive Status and nonimpaired score on the Montreal Cognitive Assessment (MoCA -- score of 22 and above)
- no indication of serious psychiatric disturbance including current major depression (based on Mental Health Screener)
- willing and able to give informed consent
- community-dwelling with subjective report of cognitive complaints with scores \>16 on the Cognitive Change Index (CCI-20)
- no evidence of dementia or mild cognitive impairment based on cognitive screening using the MoCA; scores must fall within normal limits for age, education, and sex
- no psychometric evidence of neuropsychological impairment on a modified Neuropsychological Battery from the NACC Unified Data Set, version 3
- score of 0 on the Global Clinic Dementia Rating (CDR) scale
- normal functional behavior in terms of daily activities, based on the Functional Activities Scale (FAQ)
- availability of an informant (over the phone) who can provide information about the participant's complaints using the informant version of the CCI-20, and corroborate normal activities of daily living on the FAQ and the CDR scale.
Exclusion
- Pregnant or possibly pregnant
- Claustrophobia
- Large pieces of metal in the body, particularly in the face and neck.
- Piercings or metal implants that cannot be removed from the body
- Surgery on the brain or any prior serious brain damage or disease
- Dementia or severe cognitive disorders
- use of antipsychotics, sedatives, or other medications with significant anticholinergic properties (due to potential influence on memory)
- use of prescribed 'memory enhancing' medications such as Aricept or Namenda.
Key Trial Info
Start Date :
April 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 8 2023
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT03872414
Start Date
April 1 2019
End Date
May 8 2023
Last Update
May 17 2023
Active Locations (1)
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1
University of Florida
Gainesville, Florida, United States, 32611-2250