Status:
COMPLETED
Effects of Anesthesia on Tumor Immunity and Insulin Resistance During Perioperative Period
Lead Sponsor:
Fujian Cancer Hospital
Conditions:
Anesthesia
Cervical Cancer
Eligibility:
FEMALE
18-70 years
Phase:
NA
Brief Summary
To evaluate the effects of preoperative oral carbohydrate on postoperative insulin resistance and tumor immunity in cervical cancer patients with neoadjuvant chemotherapy.
Detailed Description
Fifty-one patients undergoing neoadjuvant chemotherapy and radical hysterectomy with bilateral pelvic lymph node dissection were randomized to receive 300mL of an oral carbohydrate liquid supplement 2...
Eligibility Criteria
Inclusion
- The patients aged from 18 to 60 years old were ASA level I to II, and the informed consent was signed by the patients, which was approved by the ethics committee of the hospital.
- Cervical squamous cell carcinoma was confirmed by cervical biopsy before pathologic surgery. CT showed no distant metastasis. All patients underwent total hysterectomy, bilateral adnexectomy and pelvic lymph node dissection.
- Fasting blood glucose was normal without diabetes, impaired glucose tolerance or other metabolic diseases.
- no gastric emptying dysfunction.
Exclusion
- Dabetes
- Patients with obstruction of gastric emptying, such as pyloric obstruction, gastroesophageal reflux, nausea and vomiting, etc
- Obese (BMI \>32) or severely malnourished (BMI\<18.5)
- Distant metastasis, multiple primary cancers and recurrent tumors
- Patients with functional disorders of respiratory system, circulatory system, immune system, nervous system, urinary system and other organs
- Received blood transfusion and nutritional support within 2 weeks before surgery
- The supplement contains the sugar solution, the blood transfusion, the application glucocorticoid, the sympathetic blood vessel activity medicine in the operation.
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2018
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03872635
Start Date
January 1 2018
End Date
December 31 2018
Last Update
March 13 2019
Active Locations (2)
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1
Fuqing Zhang
Fuzhou, Fujian, China, 350014
2
Mengxia Yao
Fuzhou, Fujian, China, 350014