Status:
COMPLETED
Immune Response in Hypersensitivity Pneumonitis
Lead Sponsor:
Nabeel Hamzeh
Collaborating Sponsors:
National Jewish Health
Conditions:
Hypersensitivity Pneumonitis
Eligibility:
All Genders
18-80 years
Brief Summary
Hypersensitivity pneumonitis (HP) is an inflammatory lung disease that is caused by exposure of susceptible individuals to organic materials in the environment. It is also known by various names depen...
Detailed Description
Hypersensitivity pneumonitis (HP) is a granulomatous lung disorder triggered by exposure to one of a multitude of organic antigens. Incidence rates of HP vary by geography, season and population studi...
Eligibility Criteria
Inclusion
- Inclusion:
- Adult between the ages of 18 and 80 years old.
- Non-smoker or previous smoker quit \>6months ago.
- Radiological findings compatible with sub-acute or chronic HP4.
- Histopathological findings compatible with sub-acute or chronic HP4.
- Able to understand the consent process and procedures involved in the study.
- Exclusion:
- Unable to understand the consent process or procedures involved in the study.
- End-stage lung disease defined as predominantly honeycombing on chest CT and/or FVC\<60% and/or DLCO \<30%.
- Requiring high oxygen needs \>4L.
- Pregnancy.
- Treated with a biological agent within the past 6 months.
- Suspicion of current infection or within the past 3 months.
- Bleeding disorder or on anti-coagulants other than aspirin.
- Any co-morbid condition that increases risk of bronchoscopy including but not limited to cardiac disease, uncontrolled hypertension, uncontrolled diabetes and/or morbid obesity.
Exclusion
Key Trial Info
Start Date :
November 29 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 30 2022
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT03873649
Start Date
November 29 2018
End Date
March 30 2022
Last Update
May 18 2022
Active Locations (1)
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1
University of Iowa
Iowa City, Iowa, United States, 52242