Status:
COMPLETED
Neural Mechanisms of Mindfulness-based Cognitive Therapy (MBCT) for Posttraumatic Stress Disorder (PTSD)
Lead Sponsor:
Ohio State University
Collaborating Sponsors:
National Center for Complementary and Integrative Health (NCCIH)
University of Michigan
Conditions:
Post Traumatic Stress Disorder
Eligibility:
All Genders
18-72 years
Phase:
NA
Brief Summary
This study will examine the effects of psychotherapy as treatment for PTSD, and specifically how brain activity and brain connectivity is affected by Mindfulness Based Cognitive Therapy (MBCT) and an ...
Detailed Description
This research will see how brain activity and brain connectivity is affected by Mindfulness Based Cognitive Therapy (MBCT) and an active comparison therapy called Muscle Relaxation Therapy (MRT). Part...
Eligibility Criteria
Inclusion
- Meets current Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) criteria for PTSD (with or without Major Depressive Disorder) or subsyndromal PTSD (has qualifying trauma, has intrusive and avoidant symptoms, and at least one negativity and one arousal symptom, and significant impairment); type of trauma shall be interpersonal violence, combat, and/or sexual assault, etc.
Exclusion
- Dissociative PTSD
- Delayed-onset PTSD
- Magnetic Resonance Imaging (MRI) contraindications (e.g. metal in body, inability to be in the scanner - claustrophobia, severe back pain, etc.)
- Serious medical or neurologic conditions (e.g. stroke, seizures)
- Suicide risk
- Psychosis
- Life history of schizophrenia
- Life history of bipolar disorder
- Current substance dependence
- Other factors that preclude safe and meaningful participation in the study, at discretion of the PI and study team
Key Trial Info
Start Date :
July 29 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2024
Estimated Enrollment :
89 Patients enrolled
Trial Details
Trial ID
NCT03874793
Start Date
July 29 2019
End Date
March 1 2024
Last Update
March 5 2024
Active Locations (2)
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1
University of Michigan
Ann Arbor, Michigan, United States, 48109
2
Ohio State University
Columbus, Ohio, United States, 43210