Status:
COMPLETED
REAL-LIFE DATA OF CONSTITUTIONAL VON WILLEBRAND DISEASE IN WESTERN FRANCE (HOPSCOTcH-WILL)
Lead Sponsor:
Nantes University Hospital
Collaborating Sponsors:
CHU de Brest
University Hospital, Angers
Conditions:
Von Willebrand Diseases
Eligibility:
All Genders
Brief Summary
Von Willebrand disease (VWD) is the most common constitutional bleeding disorder in the world, caused by missing or defective von Willebrand factor (VWF). In France, VWD affects approximatively 7,000 ...
Detailed Description
von Willebrand Disease (vWD) represents the most common autosomal inherited bleeding disorders with a prevalence up to 1%; nevertheless the clinical relevant patients represent only 0.01% of the popul...
Eligibility Criteria
Inclusion
- Constitutional VWD patient, of any severity, with or without inhibitors (according to the CRMW criteria\*),
- Patient included in the research database BERHLINGO
- Patient treated or not by desmopressin or VWF/FVIII/by-passing agents available on the French market (at baseline)
- Patient who agrees to participate in the HOPSCOTcH and followed in one of the 5 investigator HTC
- Patient who are not under guardianship
- CRMW criteria for constitutional VWD definition:
- Severe forms: VWF:Ag and VWF:RCo \<5 UI/dL VWD 2A or 2M: VWF:RCo/VWF:Ag \< 0.7 and/or ratio VWF:CB/VWF:Ag \< 0.7 VWD 2B: unexplained thrombopenia and/or positive RIPA \< 0.8 mg/mL (for any value of VWF:RCo/VWF:Ag) VWD 2N: FVIII:C/VWF:Ag \< 0.6 and reduced to very reduced VWF:FVIIIB VWF:Ag \<30 UI/dL (in the absence of every previous criteria)
Exclusion
- Patients Under guardianship
Key Trial Info
Start Date :
November 13 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2019
Estimated Enrollment :
926 Patients enrolled
Trial Details
Trial ID
NCT03875924
Start Date
November 13 2019
End Date
December 31 2019
Last Update
May 19 2020
Active Locations (5)
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1
Angers University Hospital
Angers, France
2
Brest University Hospital
Brest, France
3
Le Mans Regional Hospital
Le Mans, France
4
Nantes University Hospital
Nantes, France