Status:
COMPLETED
Evaluation of Corticosteroid in Systemic Inflammatory Response Syndrome
Lead Sponsor:
Assiut University
Conditions:
Systemic Inflammatory Response Syndrome
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
Cardiac surgery and cardiopulmonary bypass (CPB) initiate a whole-body systemic inflammatory response (SIRS) characterized by the activation of leukocytes, monocytes, and the complement cascade. Multi...
Detailed Description
Investigations have shown that clinical outcomes have been improved, worsened, or unaffected by the intraoperative administration of dexamethasone or methylprednisolone Limited data suggest that low-d...
Eligibility Criteria
Inclusion
- open heart surgery with Cardiopulmonary bypass machine with relatively long bypass time more than 60 minute
- All patients Included in study with normal heart function
Exclusion
- Left ventricular ejection fraction less than 40%
- acute infection such as sepsis or pneumonia, hepatic and renal failure, cancer or any autoimmune disease
- the use of steroid within 2 week prior to operation
- coagulation abnormalities
Key Trial Info
Start Date :
September 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2020
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03876041
Start Date
September 1 2019
End Date
November 1 2020
Last Update
June 14 2021
Active Locations (1)
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1
Assuit university hospital
Asyut, Assuit, Egypt, 71511