Status:
COMPLETED
Physical Activity, Alzheimer's Disease and Cognition Relative to APOE Genotype
Lead Sponsor:
University of North Carolina, Greensboro
Collaborating Sponsors:
Wake Forest University Health Sciences
National Institute on Aging (NIA)
Conditions:
Healthy
Dementia
Eligibility:
All Genders
40-65 years
Phase:
NA
Brief Summary
Physical activity and Alzheimer's disease (PAAD-2) is a randomized control trial that will assess the effects of exercise on middle-aged (40-65 years) cognitively normal adults who have a heightened r...
Detailed Description
In this study, the investigators follow up on their past research exploring the effects of physical activity on cognitive performance and underlying mechanisms. In particular, the investigators are in...
Eligibility Criteria
Inclusion
- Family History of Alzheimer's disease, cognitive impairment
- Able to communicate in English
- Not currently meeting recommendations for physical activity (the recommendations are to exercise 3 days/week for 30+ minutes per day for longer than 3 months)
- Willing to be randomized to either study condition
- Willing to complete all study activities for 1 year
Exclusion
- Meet the criteria for clinical cognitive impairment
- Unable to perform physical activity due to known cardiovascular, metabolic, or renal disease and are symptomatic or due to orthopedic limitations
- Self-report history of confounding neurologic, psychiatric, or active severe or functionally disabling neurologic or medical diseases, or any other conditions that might limit exercise or pose a danger to the patient
- Current use of medications to treat symptoms of Alzheimer's disease, that adversely affect cognition, or that impact heart rate
- Meet the criteria for depression using the short form of the Center for Epidemiological Studies Depression Scale
- Traveling for an extended period (\>1 month) during the course of the study
Key Trial Info
Start Date :
May 23 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 21 2024
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT03876314
Start Date
May 23 2019
End Date
December 21 2024
Last Update
April 3 2025
Active Locations (1)
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1
University of North Carolina-Greensboro
Greensboro, North Carolina, United States, 27402