Status:
TERMINATED
Acute Control of Chronic Hypertension
Lead Sponsor:
Albany Medical College
Conditions:
Preeclampsia With Severe Features
Chronic Hypertension in Obstetric Context
Eligibility:
FEMALE
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to understand if administration of a personalized dose of the anti-hypertensive medication, labetalol, based on patient's history of preexisting hypertension, will be more...
Detailed Description
The investigators seek to asses the effect of preexisting hypertension on the patient's response to treatment for severe hypertension in preeclampsia with severe features. The investigators hypothesiz...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Gestational age ≥ 24 weeks
- Singleton gestation
- Chronic hypertension as defined as two elevated blood pressures (SBP ≥ 140mmHg and/or DBP ≥ 90mmHg) at least 4 hours apart before 20 weeks gestation
Exclusion
- Known allergic reaction to labetalol
- Persistent mild-moderate asthma (≥ 2 rescue inhaler uses per week in the previous month)
- Obstructive airway disease
- Bradycardia \< 70 beats/min
- Heart block \> 1st degree or history of heart failure
Key Trial Info
Start Date :
February 18 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 20 2020
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT03877692
Start Date
February 18 2019
End Date
July 20 2020
Last Update
July 22 2020
Active Locations (1)
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1
Albany Medical Center Obstetrics and Gynecology
Albany, New York, United States, 12208