Status:
WITHDRAWN
Two-day Bed Rest, Insulin Sensitivity and Muscle Protein Synthesis
Lead Sponsor:
University of Exeter
Conditions:
Healthy
Eligibility:
MALE
18-40 years
Phase:
NA
Brief Summary
The impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males
Detailed Description
To study the mechanisms underlying inactivity-induced muscle atrophy, the impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesi...
Eligibility Criteria
Inclusion
- Male
- Aged 18-40
Exclusion
- Smoker
- Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes)
- Any diagnosed cardiovascular disease (e.g. deep vein thrombosis or hypertension)
- Chronic use of any prescribed or over the counter pharmaceuticals (that may modulate muscle protein metabolism).
- A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
- Any known disorders in muscle metabolism
- Regular use of nutritional supplements (i.e. ingestion more than twice per week during the last month)
- Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).
- Allergy to lidocaine
- Recent (within the last 6 months) or current musculoskeletal injury (e.g. leg fracture)
Key Trial Info
Start Date :
September 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2021
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03877822
Start Date
September 1 2021
End Date
September 1 2021
Last Update
November 17 2021
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