Status:
COMPLETED
4-methylpyrazole and Acetaminophen Metabolism
Lead Sponsor:
University of Arizona
Conditions:
Healthy Adult Volunteers
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
Oxidative metabolism of APAP will be studied with and without 4-MP.
Eligibility Criteria
Inclusion
- Healthy
- No APAP use in previous 2 weeks
- No ingestion of alcohol or drugs that affect CYP 2E1 over previous 5 days
- No allergy to APAP or fomepizole
- BMI \< 29
Exclusion
- Pregnant or lactating
- History of alcohol abuse
- Allergy to APAP or fomepizole
- Screening LFTs above normal range
Key Trial Info
Start Date :
July 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 31 2018
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT03878693
Start Date
July 1 2018
End Date
October 31 2018
Last Update
September 26 2019
Active Locations (1)
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1
BUMCP - Department of Medical Toxicology
Phoenix, Arizona, United States, 85006