Status:
COMPLETED
Theta Burst Transcranial Magnetic Stimulation of Fronto-parietal Networks: Modulation by Mental State
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Healthy
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The purpose of this study is to improve understanding of the way transcranial magnetic stimulation (TMS), a form of non-invasive brain stimulation, affects the brain. The study hypothesis that when th...
Detailed Description
We will test the broad hypothesis that when TBS is applied during a controlled mental state, network changes will be facilitated, compared to stimulation when mental state is uncontrolled. We will foc...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Women of child bearing age can not be pregnant or trying to become pregnant
- Ability to tolerate small, enclosed spaces without anxiety
- Size compatible with scanner gantry, e. g. men over 6 feet tall that weigh more than 250 lbs, men under 6 feet tall that weigh over 220 lbs, women over 5'11" tall that weigh more than 220 lbs, or women under 5'10" tall that weigh more than 200 lbs. Subjects of these weights or greater typically have difficult fitting into the fMRI scanner properly
- Ability and willingness to give informed consent to participate
- Alcohol or drug dependence (if in remission for greater than 5 years)
- Exclusion Criteria
- History of past or current mental illness (except simple phobias)
- History of closed head injury, for example, loss of consciousness \> approximately 5 minutes, hospitalization, neurological sequela;
- Metals, implants or metallic substances within or on the body that might cause adverse effects to the subject in a strong magnetic field, or interfere with image acquisition (for example; aneurysm clips, retained particles or metal workers with exposures, neurostimulators, foil-backed transdermal patches, carotid or cerebral stents, cerebral spinal fluid (CSF) shunts; magnetic dental implants, ferromagnetic ocular implants, pacemakers, and automatic implantable defibrillators).
- Prescription or non-prescription, with psychotropic effects (birth control medications allowed)
- First-degree family members with a history of epilepsy
- History of serious neurological illness or current medical condition that could compromise brain function, such as liver failure
Exclusion
Key Trial Info
Start Date :
November 11 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 29 2022
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT04010461
Start Date
November 11 2019
End Date
March 29 2022
Last Update
October 6 2023
Active Locations (1)
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1
University of Michigan
Ann Arbor, Michigan, United States, 48170