Status:
COMPLETED
Vitamin D for Polycystic Ovary Syndrome Clomiphene Resistant Women
Lead Sponsor:
Ain Shams University
Conditions:
PCOS
Vitamin D Deficiency
Eligibility:
FEMALE
20-35 years
Phase:
PHASE4
Brief Summary
This study is determining the therapeutic effect of Vitamin D supplements to Pcos clomiphene resistant polycystic ovarian syndrome Women. Half of patients will receive Vitamin D with metformin while o...
Detailed Description
Polycystic ovary syndrome (PCOS) is considered one of the most common endocrine disorders affecting women in their reproductive age. Genetically it is thought to be involving defects in primary cellul...
Eligibility Criteria
Inclusion
- Diagnosis of PCOS as defined by the Rotterdam criteria
- Females age 20-35 years old
- BMI 18-30 kg/m2
- 1ry or secondary infertility
- Clomiphene resistant ( patients didn't - show response: ovulate to dose of 200 mg clomid per day for 3 cycles )
- Willingness to comply with study protocol for 5 months
- Willingness to give written informed consent to participate in the study
Exclusion
- Previous metformin intake
- ovarian drilling
- tubal factor as evidenced by hysterosalpingogram or laparoscope
- endometrial pathology ex., polyp
- Myometrial pathology ex., adenomyosis or fibroid
- abnormal semen parameters
- Cushing syndrome
- Hyperprolactinemia
- Adrenal secreting tumor
Key Trial Info
Start Date :
April 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 30 2019
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04010942
Start Date
April 1 2018
End Date
March 30 2019
Last Update
July 8 2019
Active Locations (1)
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1
Ain Shams University Maternity hospital
Cairo, Egypt