Status:
COMPLETED
Neuroplastic Alterations of the Motor Cortex by Caffeine
Lead Sponsor:
University Medical Center Goettingen
Conditions:
Cortical Excitability
Brain Stimulation
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
Caffeine is a psychostimulant drug. It acts as a competitive antagonist at adenosine receptors, which modulate cortical excitability as well. In deep brain stimulation (DBS), the production of adenosi...
Eligibility Criteria
Inclusion
- Male and female healthy participants between the ages of 18-45.
- Right-handed (Oldfield 1971).
- Free willing participation and written, informed consent of all subjects obtained prior to the start of the study.
- Participant's weight is above 60 kg
Exclusion
- Age \< 18 or \> 45 years old;
- Left hand dominant;
- Evidence of a chronic disease or history with a disorder of the nervous system
- History of epileptic seizures;
- Pacemaker or deep brain stimulation;
- Metal implants in the head region (metal used in the head region, for example, clips after the operation of an intracerebral aneurysm (vessel sacking in the region of the brain vessels), implantation of an artificial auditory canal);
- Cerebral trauma with loss of consciousness in prehistory;
- Existence of a serious internal (internal organs) or psychiatric (mental illness)
- Alcohol, medication or drug addiction;
- Receptive or global aphasia (disturbance of speech comprehension or additionally of speech);
- Participation in another scientific or clinical study within the last 4 weeks;
- Pregnancy
- Breastfeeding
- Intolerance to caffeine or coffee products
- Participant who has abnormal heart activity from an electrocardiography (ECG) finding
- Weight is less than 60 kg
Key Trial Info
Start Date :
July 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 19 2019
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04011670
Start Date
July 15 2019
End Date
November 19 2019
Last Update
November 29 2019
Active Locations (1)
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1
Prof. Dr. Walter Paulus
Goettigen, Lower Saxony, Germany, 37075