Status:
RECRUITING
Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease
Lead Sponsor:
University Hospital, Montpellier
Conditions:
Huntington Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Huntington disease (HD, 1.3/10 000) is an autosomal dominant disease due to an abnormal expansion of CAG triplets in HTT gene. Several pathophysiological mechanisms have been evoked, including an alt...
Detailed Description
* Design: Multicentre prospective case-control study. Centres: University Hospital of Montpellier, France; University Hospital of Bordeaux, France; University Hospital of Nimes, France; University Hos...
Eligibility Criteria
Inclusion
- General inclusion criteria:
- age ≥ 18 years-old
- national health insurance cover
- Patients inclusion criteria:
- genetically confirmed Huntington's disease diagnosis (≥ 35 CAG repeat in HTT gene exon 1)
- written informed consent
- only for patients "with lumbar puncture (LP)": patient agreement for LP
- Control inclusion criteria:
- anterior LP for medical reason with consent for biobank "Neuro" with following samples present in this biobank : 2 mL blood + 0.5 mL plasma + 0.5 mL cerebrospinal fluid
- information and non-opposition for the finality of this biobank
- paired by age with a patient (+/- 5 years difference)
Exclusion
- General exclusion criteria:
- protected by law
- Patients exclusion criteria:
- Huntington's disease stage too Evolved that may interfere with cognitive evaluations or MRI
- contraindications to brain MRI
- only for patients "with LP": contraindications to LP
- incapacity to give informed consent
- Control exclusion criteria:
- neurodegenerative of inflammatory central nervous system pathology
Key Trial Info
Start Date :
March 3 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2026
Estimated Enrollment :
135 Patients enrolled
Trial Details
Trial ID
NCT04012411
Start Date
March 3 2020
End Date
February 1 2026
Last Update
September 30 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospital of Montpellier
Montpellier, France