Status:
UNKNOWN
rTMS on Mismatch Negativity of Schizophrenia
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Schizophrenia
Mismatch Negativity
Eligibility:
All Genders
20-45 years
Phase:
NA
Brief Summary
Auditory mismatch negativity deficit is a robust neurophysiological biomarker of schizophrenia. Repetitive transcranial magnetic stimulation (rTMS) is a neuromodulation method and can be used to modul...
Eligibility Criteria
Inclusion
- diagnosis of schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision
- mean amplitude of MMN at FCz greater than -0.7 ㎶
- moderate or milder disease severity (scoring 4 or below according to clinical global rating scale)
Exclusion
- unwillingness or inability to cooperate with the experiments
- with mental retardation, epilepsy, or other major brain pathology (e.g. cerebrovascular accidents or major head injury)
- with alcohol or other illicit substance abuse
- with major debilitating systemic diseases or difficulties in ambulation
- with hearing impairments as screened by audiometry over 500 Hz, 1000 Hz and 6000 Hz
- with pacemaker, intra-ocular metal foreign body, intracerebral vessel clip, artificial cardiac valve, electronic implant in the body, claustrophobia, or previous surgery involving the brain
- being pregnant or to be pregnant during the clinical trial. A pre-TMS evaluation scale will be applied to ensure the safety
Key Trial Info
Start Date :
September 5 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2021
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT04012684
Start Date
September 5 2019
End Date
February 28 2021
Last Update
August 10 2020
Active Locations (1)
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1
Department of Psychiatry, National Taiwan University Hospital
Taipei, Taiwan, 1002