Status:
WITHDRAWN
Obstructive Sleep Apnea Treatment and Insulin Sensitivity in Pregnancy
Lead Sponsor:
Barnes-Jewish Hospital
Collaborating Sponsors:
Washington University School of Medicine
Conditions:
Obstructive Sleep Apnea
Pregnancy Related
Eligibility:
FEMALE
20-39 years
Phase:
NA
Brief Summary
This study will evaluate the effect of treatment of obstructive sleep apnea on insulin sensitivity in pregnant women. Women in their third trimester of pregnancy will be randomized to receive treatmen...
Detailed Description
Obstructive Sleep Apnea (OSA) worsens over pregnancy and is related to increased risk of gestational diabetes. Despite the fact that sleep disturbances are common during pregnancy, OSA remains under-d...
Eligibility Criteria
Inclusion
- 28-32 weeks pregnant
- Age 20-39
- BMI 30-40 kg/m2 pre-pregnancy (or first trimester)
- Obstructive Sleep Apnea (AHI≥15)
- Have a singleton pregnancy
Exclusion
- Diabetes (GDM, type 1 or type 2)
- Using beta blockers or glucocorticoids
- Have children who are ≤2 yrs old (risk of disrupted sleep)
- Diagnosed sleep disorders (other than sleep apnea)
- Night work schedule
- Diagnosed congestive heart failure
- Diagnosed lung disease (e.g. asthma, chronic obstructive pulmonary disease)
- Pre-gestational hypertension
Key Trial Info
Start Date :
July 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 30 2023
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04013399
Start Date
July 1 2020
End Date
March 30 2023
Last Update
July 27 2023
Active Locations (1)
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1
Washington University in St. Louis
St Louis, Missouri, United States, 63127