Status:
COMPLETED
Fiber Fermentation Kinetics Inside the Gut, and Utilization of Bacterial Metabolites
Lead Sponsor:
Wageningen University
Collaborating Sponsors:
University Medical Center Groningen
Conditions:
Metabolism
Dietary Fiber
Eligibility:
MALE
18-60 years
Phase:
NA
Brief Summary
In this study, the life course of SCFA and their regulatory role in human metabolism will be traced using a nose-intestine catheter. The investigators have methodological questions: investigate the en...
Detailed Description
Background: Nowadays there is a strong interest in optimising human health through manipulation of non-digestible carbohydrates (NDC). NDC are fermented by the microbiota, hereby producing fermentatio...
Eligibility Criteria
Inclusion
- Males
- Age 18-60yrs
- BMI between 18.5 and 30 kg/m2
- Regular bowel movement (defaecation on average once a day)
- Signed informed consent
Exclusion
- Having a history of medical or surgical events that, in the opinion of the Investigator, may either put the subject at risk because of participation in the study, or influence the results of the study (e.g. diabetes, cardiovascular disease, gastrointestinal disease, renal failure, cancer, infectious disease, nose/throat).
- Use of any prescribed or non-prescribed medication (other than paracetamol) including antacids, analgesics, and herbal remedies during the three (3) weeks prior to study start.
- Carrying a pacemaker or any other (implanted) medical electronic device
- Smoker
- Unstable body weight (weight gain or loss \>5kg in the past 3 months prior to the study start)
- Use of antibiotics within 3 months of starting the study or planned during the study
- Use of pro- or prebiotics (e.g. galacto-oligosaccharides, fructo-oligosaccharides)
- Constipation/infrequent bowel movement
- Abuse of drugs/alcohol (alcohol: \>4 consumptions/day or \>21 consumptions/week)
- Participation in another biomedical study
- Having diarrhoea within 2 months prior to the study start
- Personnel of Wageningen University, Division of Human Nutrition, their partner and their first and second degree relatives
- Current participation in other research from the Division of Human Nutrition
- Not willing to have an X-ray
- Having blood vessels that are too difficult for inserting a cannula
- Having a hemoglobin of \<8.4 mmol/L
Key Trial Info
Start Date :
July 8 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 17 2019
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT04013607
Start Date
July 8 2019
End Date
October 17 2019
Last Update
October 14 2020
Active Locations (1)
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1
Wageningen University
Wageningen, Gelderland, Netherlands, 6708 WE