Status:
UNKNOWN
Coronary Microvascular Dysfunction in Chronic Kidney Disease
Lead Sponsor:
University Hospital Birmingham NHS Foundation Trust
Conditions:
Kidney Disease, Chronic
Myocardial Dysfunction
Eligibility:
All Genders
18+ years
Brief Summary
This is an observational study assessing coronary microvascular function in healthy controls with normal kidney function, living kidney donors, pre-dialysis patients with chronic kidney disease stage ...
Detailed Description
The clinical syndrome of uraemic cardiomyopathy is prevalent in end stage renal disease and is associated with pathological cardiovascular changes including left ventricular hypertrophy, diastolic dys...
Eligibility Criteria
Inclusion
- Healthy control with normal renal function
- Living kidney donor who has donated \>12 months prior to enrolment in study
- Chronic kidney disease stage 5 who are pre-dialysis or on peritoneal dialysis
- Able to provide written informed consent
Exclusion
- Pregnancy
- Known ischaemic heart disease
- Diabetes mellitus
- Uncontrolled hypertension
- Evidence of 2nd or 3rd degree AV block or sick sinus syndrome in absence of a pacemaker
- History of allergic/adverse reaction to adenosine or Sonovue
- History of long QT syndrome
- Severe hypotension
- Significant valvular heart disease
- Significant chronic obstructive pulmonary disease or asthma with bronchospasm
- Unstable angina not controlled with medication
- Concurrent use of dipyridamole
- Decompensated heart failure
- Poor echo acoustic windows
- Chronic kidney disease stage 5 on haemodialysis
Key Trial Info
Start Date :
May 7 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2020
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04014127
Start Date
May 7 2019
End Date
December 31 2020
Last Update
July 10 2019
Active Locations (1)
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1
Queen Elizabeth Hospital
Birmingham, United Kingdom, B15 2TH