Status:
COMPLETED
GCF HIF-1α, VEGF and TNF-α Levels in G-AgP Patients Before and After Periodontal Treatment.
Lead Sponsor:
Aydin Adnan Menderes University
Conditions:
Aggressive Periodontitis, Generalized
Periodontal Health
Eligibility:
All Genders
25-45 years
Phase:
NA
Brief Summary
Hypoxia-inducible angiogenic pathway involving hypoxia inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor (VEGF) and tumour necrosis factor- alpha (TNF-α) may regulate the several b...
Detailed Description
Study Population and Clinical Examination A total of 40 individuals were recruited for the present study. Inclusion criteria included: 1) aged 25 to 45 years 2) non-smokers with no history of smoking...
Eligibility Criteria
Inclusion
- aged 25 to 45 years
- non-smokers with no history of smoking
- having at least 20 natural teeth.
Exclusion
- having any diagnosed medical disorders such as diabetes mellitus, cardiovascular diseases, rheumatoid arthritis, immunological and mucocutaneous diseases
- usage of antibiotics, non-steroidal anti-inflammatory drugs and immunosuppressive agents within the past 6 months
- having any non-inflammatory destructive periodontal disease
- nonsurgical/surgical periodontal therapy received in the past year
- having a restorative and endodontic treatment requirement
- having orthodontic appliances or a removable partial denture
- pregnant/ lactating/ postmenopausal females.
Key Trial Info
Start Date :
December 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 15 2018
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04020315
Start Date
December 1 2017
End Date
September 15 2018
Last Update
July 17 2019
Active Locations (1)
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1
Adnan Menderes University, Faculty of Dentistry, Department of Periodontology
Aydin, Turkey (Türkiye), 09100