Status:
COMPLETED
Effects of Exercise on Metabolic Parameters in Classical Homocystinuria
Lead Sponsor:
University of Lausanne
Conditions:
Homocystinuria
Eligibility:
All Genders
18-60 years
Brief Summary
The aim of this research project is to compare the effect of an aerobic exercise session in two different populations. Sampling biological material and collecting health-related personal data entails ...
Detailed Description
Background Among genetic causes of hyperhomocysteinemia, classical homocystinuria, manifest not only with vascular diseases but also with neurological symptoms. This is related to the higher homocyste...
Eligibility Criteria
Inclusion
- Inclusion Criteria for subjects:
- Informed consent as documented by signature
- Confirmed biallelic mutation of cystathionine beta-synthase deficiency gene (homozygous or compound heterozygous) in an accredited Laboratory
- Continuation of their regular treatment under same dose (e.g. vitamin B6, B9 and B12, betaine) as prior to the study inclusion
- Inclusion Criteria for controls:
- \- Healthy
- Exclusion Criteria:
- Any clinically instable concomitant disease
- Individuals with acute cardiac events, syncope, rhythm disturbances or unstable hypertension in the past 6 months
- Individuals with vitamins B9 or B12 deficiencies
- Homocysteine \> 100 µmol/l (for subjects)
- Homocysteine \> 20 µmol/l (for controls)
Exclusion
Key Trial Info
Start Date :
July 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2020
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT04021732
Start Date
July 1 2019
End Date
December 1 2020
Last Update
March 30 2021
Active Locations (2)
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1
Département de physiologie
Lausanne, Canton of Vaud, Switzerland, 1005
2
Lausanne University Hospitals
Lausanne, Canton of Vaud, Switzerland, 1011