Status:
COMPLETED
EEG Characteristics in ECT
Lead Sponsor:
University of New Mexico
Conditions:
Electroconvulsive Therapy
Direct Current Electroencephalogram
Eligibility:
All Genders
18-65 years
Phase:
EARLY_PHASE1
Brief Summary
The investigators will be examining slow-wave characteristics in depressed patients receiving electroconvulsive therapy (ECT) using direct current electroencephalogram (dcEEG) by anesthesia induction ...
Detailed Description
This is a pilot project using dcEEG to look at infra-slow waves in depressed patients receiving ECT randomized to ketamine or methohexital where ketamine suppresses infra-slow waves. The rationale for...
Eligibility Criteria
Inclusion
- Structured Clinical Interview for DSM-5 will confirm diagnosis of MDD or BPD-depressed (with or without psychotic features
- The clinical indications for ECT including treatment resistance or a need for a rapid and definitive response;
- Hamilton Depression Rating Scale 24-item (HDRS-24) \> 21; and
- Age range between 18 and 65 years of age.
Exclusion
- Defined neurological or neurodegenerative disorder (e.g., history of head injury with loss of consciousness \> 5 minutes, epilepsy, Alzheimer's disease);
- Other psychiatric conditions (e.g., schizophrenia, schizoaffective disorder, bipolar disorder)
- Current drug or alcohol use disorder, except for nicotine and marijuana
- Adults unable to consent, pregnant women, prisoner
- Non-English speakers
- Patients that cannot tolerate Methohexital and Ketamine.
Key Trial Info
Start Date :
October 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2020
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT04022226
Start Date
October 1 2019
End Date
October 1 2020
Last Update
October 26 2024
Active Locations (1)
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1
University of New Mexico Mental Health Center
Albuquerque, New Mexico, United States, 87106