Status:
COMPLETED
A Single Intraarticular Injection of Platelet-Rich Plasma on Pain and Physical Function in Patients With Ankle OA
Lead Sponsor:
Kaohsiung Veterans General Hospital.
Conditions:
Ankle Osteoarthritis
Eligibility:
All Genders
20-70 years
Phase:
NA
Brief Summary
Platelet-rich plasma (PRP) has been reported to be an effective treatment for knee osteoarthritis (OA). The application in ankle OA has rarely been investigated. The aim was to evaluate the efficacy a...
Detailed Description
Methods: In a prospective study, patients with symptomatic ankle OA for at least 6 months were recruited. Patients received a single injection of 3-ml of PRP into symptomatic ankles. The primary outco...
Eligibility Criteria
Inclusion
- Age of at least twenty years
- Ankle pain lasted for at least 6 months, despite conservative treatment or inability to tolerate the side effects of medications
- Ankle radiographs taken within 6 months (reviewed by the senior author) were equivalent to grade 1-4 osteoarthritis by the Kellgren Lawrence grading system
- Average ankle pain of \> 3cm on a 10-cm visual analog scale (VAS)
- Radiological evidence of bilateral ankle osteoarthritis was accepted if VAS pain in the contralateral ankle was \< 3 cm
- Normal activity level, not bedridden or confined to a wheelchair, able to walk 30 meters without the aid of a walker, crutches or cane
- No use of physical therapy or changes in shoes or orthotic devices during the study
Exclusion
- Pregnancy or lactation in women
- Lower leg trauma in a location other than within the ankle
- Previous surgery involving the spine, hip or knee
- The presence of an active infection of the ankle
- Surgery involving the affected ankle within the previous 12 months
- Intraarticular steroid or hyaluronate injection in the ankle within the previous 6 months
- Treatment with anticoagulants or immunosuppressives
- History of rheumatoid arthritis, gout, or other inflammatory arthropathy
- The presence of visual or vestibular impairments
- Poor health status (such as a neoplasm, diabetes mellitus, or paresis) that would interfere with the assessments
Key Trial Info
Start Date :
July 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 30 2019
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT04022928
Start Date
July 1 2018
End Date
May 30 2019
Last Update
July 19 2019
Active Locations (1)
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1
Department of Physical Medicine and Rehabilitation, Veterans General Hospital Kaohsiung
Kaohsiung City, Taiwan, 813