Status:
UNKNOWN
The Effect of Different Reconstruction Methods on Anterior Resection Syndrome
Lead Sponsor:
Third Affiliated Hospital, Sun Yat-Sen University
Conditions:
Rectal Cancer
Low Anterior Resection Syndrome
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
The incidence of prerectal resection syndrome (LARS) after middle and low rectal cancer surgery is as high as 70%, which seriously affects the quality of life of patients. Studies have shown that colo...
Detailed Description
The incidence of prerectal resection syndrome (LARS) after middle and low rectal cancer surgery is as high as 70%, which seriously affects the quality of life of patients. LARS may be related to the i...
Eligibility Criteria
Inclusion
- 20 years old ≤80 years old, regardless of gender, signed informed consent,
- BMI≤kg/m\^2,
- Primary rectal lesions are pathologically diagnosed as rectal adenocarcinoma by endoscopic biopsy,
- The distance between the tumor and the anal margin is 5cm to 12cm,
- Preoperative tumor stage is T1-4N0-3M0,(according to AJCC-8th TNM tumor staging),
- Normal anorectal function and LARS score ≤20.
Exclusion
- Patients with inflammatory bowel disease, chronic constipation, irritable bowel syndrome and other intestinal diseases that may affect bowel function,
- Patients with large tumors or extensive invasion of surrounding tissues and organs, TME is not applicable,
- Long-term use of drugs (such as morphine) that may affect bowel function,
- Patients with a history of abdominal, pelvic and anorectal surgery,
- Patients with severe mental illness or who cannot be evaluated due to cultural or psychological reasons.
Key Trial Info
Start Date :
September 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2022
Estimated Enrollment :
138 Patients enrolled
Trial Details
Trial ID
NCT04023448
Start Date
September 1 2019
End Date
September 1 2022
Last Update
July 17 2019
Active Locations (1)
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1
The Third Affiliated Hospital of Sun Yat-Sen university
Guanzhou, Guangdong, China, 510000