Status:
COMPLETED
Antimicrobial-free Production of Beef Cattle's Affect on Gut Microbiome
Lead Sponsor:
Purdue University
Collaborating Sponsors:
Colorado State University
University of Minnesota
Conditions:
Diet Modification
Eligibility:
All Genders
21-69 years
Phase:
NA
Brief Summary
The primary purpose of this study is to assess whether consuming foods from animals raised with antimicrobial medications influences gut health in adults between the ages of 21-69 years old. Antimicro...
Detailed Description
The researchers plan to investigate differences in the resistome (i.e., populations of antimicrobial resistance genes) and microbiome (populations of bacteria) in feces obtained from people when they ...
Eligibility Criteria
Inclusion
- Male or female, 21-69 years old;
- BMI 22.0-34.9 kg/m2;
- Fasting serum total cholesterol \<240 mg/dL, low-density lipoprotein cholesterol \<160 mg/dL, triglycerides \<400 mg/dL, and glucose \<110 mg/dL;
- Systolic/diastolic blood pressure \<140/90 mmHg;
- Body weight stable (± 4 kg in previous 3 mo);
- Medication use stable for 6 months prior and not using medications or supplements known to impact gut function;
- No use of topical, oral or parenteral antibiotic medications in previous 6 months.
- Non-smoking;
- Physical activity regimen stable for 3 months prior;
- Not drinking more than 2 alcoholic drinks per day;
- No history of gastrointestinal disorders, surgeries or cancers;
- Non-pregnant and not lactating
- No acute illness and non-diabetic;
- Willing and able to consume the prescribed diets that may include meat, dairy and gluten-containing foods and beverages.
Exclusion
- Male or female, \< 20 or \>70 years old;
- BMI \< 21.9- \>35 kg/m2;
- Fasting serum total cholesterol \>240 mg/dL, low-density lipoprotein cholesterol \>160 mg/dL, triglycerides \>400 mg/dL, and glucose \>110 mg/dL;
- Systolic blood pressure \>140 mmHg, diastolic blood pressure \>90 mmHg;
- Body weight stable for \< 3 months prior (±3 kg);
- Stable physical activity regimen \< 3 months prior;
- Medication use unstable for 6 months prior and using medications or supplements known to impact gut function;
- Smoking;
- Drinking more than 2 alcoholic drinks per day;
- Diabetic;
- A history of gastrointestinal disorders, GI surgeries or GI cancers;
- Pregnant or lactating
Key Trial Info
Start Date :
January 4 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 4 2022
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT04023604
Start Date
January 4 2021
End Date
March 4 2022
Last Update
September 28 2022
Active Locations (1)
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1
Dept. Foods and Nutrition, Purdue University
West Lafayette, Indiana, United States, 47907