Status:
UNKNOWN
Effects of Pine Cone Extract on Serum IgE Levels in Perennial Rhinitis
Lead Sponsor:
University of South Florida
Conditions:
Perennial Allergic Rhinitis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The medicinal properties of pinecones have been used for years to treat a variety of illnesses. In the mouse model, an extract of pine cones, poly-phenylpropanoid-polysaccharide complex (PPC), has bee...
Detailed Description
The study will be a parallel two-arm, double-blind design. The 80% power calculation was based upon preliminary data showing a greater than 30% reduction of total serum IgE in PPC recipients. This pow...
Eligibility Criteria
Inclusion
- Subjects with perennial allergic rhinitis with or without seasonal allergic rhinitis
- Male or female participants must be 18 years of age or older
Exclusion
- Subjects receiving subcutaneous allergen immunotherapy or monoclonal anti-IgE (omalizumab)
- Subject with hypersensitivity to PPC
- Pregnant subjects (lactating post-partum women will be allowed to participate)
- Subjects who are unable to cooperate/comply with study procedures or communicate with investigator in order to successfully complete the study
- Subjects with severe skin disorders such as atopic dermatitis, dermatographism, psoriasis who could not have allergy skin testing and who have no prior skin testing completed within 3 years
- Subjects with an infirmity, disability, or geographical location which seems likely to prevent regular attendance for patient visits
Key Trial Info
Start Date :
March 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2023
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT04024033
Start Date
March 1 2011
End Date
October 1 2023
Last Update
May 10 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Usf Asthma Allergy and Immunology Cru
Tampa, Florida, United States, 33613