Status:
UNKNOWN
DiagnosE Using the Central veIn SIgn
Lead Sponsor:
Nottingham University Hospitals NHS Trust
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18-65 years
Brief Summary
There is currently no agreement on the best way to diagnose Multiple Sclerosis (MS). Frequently, people suspected of having MS have a standard MRI scan and undergo a 'lumbar puncture' (a thin needle i...
Detailed Description
The North American Imaging in MS Cooperative has reviewed the utility of the central vein sign (CVS) in the diagnosis of MS in 2015. They concluded that "To formally establish the clinical value of th...
Eligibility Criteria
Inclusion
- Aged 18 to 65 years.
- Presentation with a typical clinically isolated syndrome (Thompson et al. 2017) for diagnostic evaluation of MS.
Exclusion
- Fulfils the diagnosis of MS, as defined by the 2017 revision of McDonald diagnostic criteria (Thompson et al. 2017).
- Unwilling or unable to comply with the requirements of this protocol including the presence of any condition (physical, mental, or social) that, in the opinion of the PI, is likely to affect the participant's ability to comply with the study protocol.
- Unable to provide informed consent.
- Contraindication or inability to undergo MRI due to metal or metal implants, pregnancy, claustrophobia, pain, spasticity, or excessive movement related to tremor.
Key Trial Info
Start Date :
November 6 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2022
Estimated Enrollment :
115 Patients enrolled
Trial Details
Trial ID
NCT04024969
Start Date
November 6 2019
End Date
November 1 2022
Last Update
March 4 2020
Active Locations (4)
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1
Cardiff & Vale University Lhb
Cardiff, United Kingdom
2
Barts Health Nhs Trust
London, United Kingdom
3
Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom
4
Oxford University Hospitals Nhs Foundation Trust
Oxford, United Kingdom