Status:
UNKNOWN
Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods
Lead Sponsor:
Kocaeli University
Conditions:
Generalized Aggressive Periodontitis
Chronic Periodontitis
Eligibility:
All Genders
Brief Summary
Generalized aggressive Periodontitis (GAgP) and chronic periodontitis (CP) are inflammatory diseases. Little is known about molecular changes and signaling cascade of host response. Inflammatory disea...
Detailed Description
Generalized aggressive Periodontitis (GAgP) is a multifactorial, destructive, inflammatory and complex disease. The progression of the disease is undercontrol of immunologic, microbiologic, environmen...
Eligibility Criteria
Inclusion
- Inclusion criteria for aggressive periodontitis patients;
- The periodontal diagnosis of subjects with GAgP was established on the basis of clinical and radiographic criteria and was defined by the 1999 International World Workshop for a Classification of Periodontal Diseases and Conditions (Lang et al., 1999),
- Between 18 and 35 years of age,
- Otherwise healthy,
- The bone loss estimation was radiographically performed in each patient for the assessment of the extent and severity of alveolar bone loss.
- Inclusion criteri for chronic periodontitis patients;
- Had at least 20 teeth,
- Exhibiting \>30% of measured sites with 5mm clinical attachment loss,,
- Had bleeding on probing (BOP) at \>50% of the proximal sites.
- Inclusion criteri for control individuals;
- \- Overall healthy individuals (dental, periodontal and systemically)
- Exclusion Criteria for all individuals;
- Had any known systemic diseases or conditions that can/could influence the periodontal status (cancer, cardiovascular and respiratory diseases),
- Any history of hepatitis and/or HIV infection,
- Immunosuppressive chemotherapy,
- Current pregnancy, planning a pregnancy or lactation,
- Requirement for antibiotic prophylaxis,
- Had oral diseases other than GAgP,
- Oongoing orthodontic therapy,
- A history of antibiotic therapy, or periodontal treatment within the preceding six months
Exclusion
Key Trial Info
Start Date :
September 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 15 2022
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04026828
Start Date
September 1 2019
End Date
July 15 2022
Last Update
July 25 2019
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