Status:
COMPLETED
Biologic Mechanisms of Early Exercise After Intracerebral Hemorrhage
Lead Sponsor:
Johns Hopkins University
Conditions:
Intracerebral Hemorrhage
Acute Ischemic Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study aims to determine whether in-bed cycle ergometry, early in the hospital course after a brain hemorrhage could balance damaging and reparative inflammation in the brain. Inflammatory factors...
Eligibility Criteria
Inclusion
- Supratentorial intracerebral hemorrhage with or without intraventricular hemorrhage
- Pre-morbid modified Rankin Score of 0-2
- Patient must be able to provide informed consent or have a legally authorized representative to provide consent on patient's behalf
Exclusion
- Patients with known inflammatory conditions, infection requiring antibiotics or pregnancy
- Patients receiving daily anti-inflammatory medications including but not limited to prednisone, methotrexate, non-steroidal anti-inflammatory medications (ibuprofen, naproxen, indomethacin, celecoxib) and aspirin \>325mg
- Glasgow Coma Score (GCS) 3 48 hours after admission
- Patients in whom withdrawal of life support is being considered by surrogate decision makers
- Injury to the lower extremities, hips or pelvis, weight \>250 kg (weight limit of cycle), or body habitus precluding normal function of cycle
Key Trial Info
Start Date :
March 2 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 24 2021
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT04027049
Start Date
March 2 2019
End Date
February 24 2021
Last Update
May 1 2024
Active Locations (1)
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1
Johns Hopkins University, Department of Neurology
Baltimore, Maryland, United States, 21287