Status:
COMPLETED
a Single Intraarticular Injection of PRP for Early Knee OA
Lead Sponsor:
Kaohsiung Veterans General Hospital.
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
20-70 years
Phase:
NA
Brief Summary
This study aimed to investigate the efficacy of a single intraarticular injection of PRP for the treatment of early knee OA.
Detailed Description
Platelet-rich plasma (PRP) has been reported to be effective for the treatment of knee osteoarthritis (OA). This study aimed to investigate the efficacy of a single intraarticular injection of PRP for...
Eligibility Criteria
Inclusion
- aged 20-70 years
- symptomatic knee OA with pain for at least 6 months despite conservative treatment such as analgesics, NSAIDs and/or physical therapy
- average knee pain of at least 30 mm on a 100-mm visual analog (VAS) scale
- grade 1 or 2 knee OA according to the Kellgren-Lawrence grading system based on -radiographs taken within the previous 6 months
- Radiological evidence of bilateral knee OA was accepted if global pain VAS in the contralateral knee was less than 30 mm.
Exclusion
- previous orthopedic surgery on the spine or lower limbs
- disabling OA of either hip or foot
- knee instability or marked valgus/varus deformity
- history of severe knee trauma; intraarticular injections into the knee in the past 6 months
- infections or skin diseases around the target knee
- women ascertained or suspected pregnancy or lactating
- presence of malignancy, hematological disease, collagen vascular diseases, or autoimmune diseases;
- therapy with anticoagulants or anti-aggregating agent
- serious medical conditions that would interfere with the assessments during the study.
Key Trial Info
Start Date :
January 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2017
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT04027738
Start Date
January 1 2017
End Date
December 30 2017
Last Update
July 22 2019
Active Locations (1)
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1
Department of Physical Medicine and Rehabilitation, Veterans General Hospital,
Kaohsiung City, Taiwan, 813