Status:
COMPLETED
Sickle Cell Trait and Exercise, Effect of Hot Environment
Lead Sponsor:
University of the French West Indies and French Guiana
Collaborating Sponsors:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Sickle Cell Trait
Environmental Exposure
Eligibility:
MALE
18-30 years
Phase:
NA
Brief Summary
The heterozygous form of sickle cell disease is clinically asymptomatic. Nevertheless, it was observed that, the sickle cell trait is associated with serious medical complications especially during in...
Detailed Description
Introduction The sickle cell disease is an inherited disorder characterized by abnormal hemoglobin called hemoglobin S or sickle hemoglobin in red blood cells of subjects. The homozygous form (hemogl...
Eligibility Criteria
Inclusion
- BMI between 19 and 25kg/m2,
- Be living in the Caribbean for at least 6 months health
- Be physically active (≥ 1350 METs/week)
- No history of heat stroke during exercise
- No taking any medications
- Not regularly consuming alcohol
- Have the ability and willingness to issue consent written, free and enlightened
Exclusion
- Have any other hemoglobinemic status than AA or AS.
- Weight gain or loss of more than 2 kg in the last 6 month.
- Food allergy to any of ingredients coming into the composition of test meals or that may result from a cross-contamination during manufacture: eggs and eggs products, gluten, milk and milk-based products (including lactose), soybean and soy products, fruit hulls (almonds, hazelnuts, walnuts, cashew nuts, pecan, macadamia, Brazil, Queensland, pistachios) and products made of these fruits.
- Monitoring a particular diet
- Any chronic metabolic pathology, cardiovascular, neurovascular, renal, respiratory, neuromuscular, musculoskeletal or articular known
- Any disorder of the ear (infections, tumors, perforated eardrums, polyps)
- Any infectious disease or inflammatory and infectious condition
Key Trial Info
Start Date :
September 25 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2019
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT04028791
Start Date
September 25 2017
End Date
July 1 2019
Last Update
July 23 2019
Active Locations (1)
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1
ACTES laboratory
Pointe-à-Pitre, Guadeloupe, 97157