Status:
TERMINATED
Effect of Dried Fruit Intake on Acid-base Balance
Lead Sponsor:
Tufts University
Collaborating Sponsors:
Tufts Medical Center
Conditions:
Acid-Base Balance Disorder
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
Most adults consume acid-producing diets because their high intake of protein and/or cereal grains in relation to their intake of fruits and vegetables. This study is being done to determine whether a...
Detailed Description
Most adults consume acid-producing diets because their intake of protein and/or cereal grains is high in relation to their intake of fruits and vegetables. Supplementation with alkaline salts such as ...
Eligibility Criteria
Inclusion
- usual self-reported fruit intake not greater than 2.5 servings per day
- adequate dentition to chew dried fruit
- willing to avoid potassium supplements during the study
- willing to avoid antacids other than Pepto Bismol during the study
Exclusion
- Conditions
- diabetes or fasting plasma glucose on screening \>125 mg/dl
- untreated thyroid disease
- untreated parathyroid disease
- cirrhosis
- unstable heart disease
- osteoporosis of the spine or hip
- alcohol use \> 2 drinks per day
- chronic diarrheal syndrome
- estimated glomerular filtration rate \< 50 ml/min
- serum potassium \>5.3 meq/L
- abnormal serum calcium
- dysphasia
- malabsorption
- inflammatory bowel disease
- celiac disease
- chronic constipation
- gastric bypass surgery
- non-English speaking Medications
- potassium sparing diuretics
- oral glucocorticoids
- immunosuppressant drugs
- anabolic steroids in last 6 months
- estrogen in last 6 months
- osteoporosis treatment in the last 12 months with teriparatide abaloparatide calcitonin raloxifene denosumab
- osteoporosis treatment with a bisphosphonate in the last 2 years
- regular use of antacids \> 3 times per week
- regular use of laxatives \> 3 times per week
- any medication taken to alter appetite
Key Trial Info
Start Date :
August 27 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 17 2020
Estimated Enrollment :
109 Patients enrolled
Trial Details
Trial ID
NCT04030351
Start Date
August 27 2018
End Date
March 17 2020
Last Update
October 29 2020
Active Locations (1)
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1
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, United States, 02111