Status:
COMPLETED
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Depression in Parkinson's Disease (PD)
Lead Sponsor:
Assiut University
Conditions:
Depression in Parkinson's Disease
Eligibility:
All Genders
45-75 years
Phase:
NA
Brief Summary
This study aims to assess the therapeutic role of rTMS on parkinson's patients with depression. Patients diagnosed with Parkinson's Disease and depression will be recruited. All patients will be admit...
Detailed Description
This study aims to assess the therapeutic role of rTMS on parkinson's patients with depression. Thirty PD patients with depression using United Kingdom (UK ) bank criteria for PD will be recruited fro...
Eligibility Criteria
Inclusion
- All patients with Parkinson's Disease who were diagnosed according to UK bank criteria for PD, Aged 45-75 years, with criteria for depression (BDI \> or = 14), and consent obtained from the patient or his caregiver.
Exclusion
- History of repeated head injury
- History of repeated cerebrovascular strokes
- History of defined encephalitis
- Oculogyric crisis, supranuclear gaze palsy
- Family history of more than one relative
- History of drug intake as antipsychotics or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposure
- Moderate and Severe depression (Hamilton Depression Rating Scale score \>16)
- severe dysautonomia
- Cerebellar signs
- Babinski sign
- Strictly unilateral features after 3 years
- Hydrocephalus or intracranial lesion on neuroimaging
- We also excludes patients with intracranial metallic devices or with pacemakers or any other device.
- patients with cognitive impairment (Mini-Mental Status Examination\< 24)
Key Trial Info
Start Date :
July 15 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 15 2019
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04030923
Start Date
July 15 2018
End Date
March 15 2019
Last Update
July 25 2019
Active Locations (1)
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1
Assuit University
Asyut, Egypt, 11517