Status:
COMPLETED
Treatment Patterns, Outcomes and Testing in EGFRm NSCLC Patients With EGFR TKI 1L Across Europe (REFLECT)
Lead Sponsor:
AstraZeneca
Conditions:
Lung Cancer
Eligibility:
All Genders
Brief Summary
Multinational, multi-center medical record review to describe the treatment patterns, clinical outcomes, and EGFR / T790M testing practices in EGFR-mutated advanced NSCLC patients receiving first-line...
Detailed Description
The aim is to generate real-life data on treatment patterns of the EGFR-mutated advanced NSCLC patients receiving first- or second-generation EGFR TKI in first line of therapy as provided per routine ...
Eligibility Criteria
Inclusion
- Confirmed diagnosis of locally advanced unresectable or metastatic NSCLC;
- Aged at least 18 years at first diagnosis of locally advanced/metastatic NSCLC;
- Lab-confirmed EGFR mutation;
- Received a first- or second-generation EGFR TKI as first-line treatment for advanced/metastatic disease;
- First-line EGFR TKI (afatinib, gefitinib, erlotinib) initiated between January 1, 2015 and June 30, 2018;
- Patients may be alive or deceased at the time of medical record review.
Exclusion
- Patients enrolled at any time in an interventional clinical trial for an experimental treatment related to EGFR-mutated NSCLC;
- Patients receiving any systemic therapy for locally advanced or metastatic NSCLC prior to first-line EGFR TKI treatment in the locally advanced/metastatic setting;
- Missing or unknown data on any of the following key study dates:
- Date of initial NSCLC diagnosis;
- Date of first diagnosis of or progression to advanced/metastatic NSCLC;
- Date of first-line EGFR TKI initiation for advanced/metastatic disease;
- Date of death or last available follow-up.
Key Trial Info
Start Date :
May 7 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2019
Estimated Enrollment :
896 Patients enrolled
Trial Details
Trial ID
NCT04031898
Start Date
May 7 2019
End Date
December 31 2019
Last Update
December 23 2020
Active Locations (1)
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1
Research Site
Wien, Bulgaria, 1140