Status:
COMPLETED
Modification of Pavlovian and Instrumental Learning in Human Addiction
Lead Sponsor:
Charite University, Berlin, Germany
Conditions:
Healthy
Alcohol Use Disorder (Mild vs. Moderate to Heavy)
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The project aims at investigating modifications of environmental factors (i.e. cues and stress) relevant for learning mechanisms in addictive disorders.
Detailed Description
Project C02 aims at investigating modifications of environmental factors (i.e. cues and stress) relevant for learning mechanisms in addictive disorders. The investigators will examine non-treatment se...
Eligibility Criteria
Inclusion
- Men and women aged 16-32 years, 33-49 years, and aged 50-65 years
- Mild, moderate to heavy alcohol-use disorder (AUD) according to DSM-5 criteria (mild: 2-3 AUD criteria; moderate: 4-5 AUD criteria; heavy: 6 or more AUD criteria); not clinically requiring detoxification (as confirmed by an independent board-certified psychiatrist); AUD patients can have mild to moderate cannabis use disorder as well as tobacco use disorder
- Ability to provide fully informed consent and to use self-rating scales
- Willingness to use an android phone
- Sufficient understanding of the German language
Exclusion
- Lifetime history of DSM-5 bipolar disorder, schizophrenia or schizophrenia spectrum disorder, or substance dependence other than alcohol or nicotine or cannabis dependence. Severe alcohol and cannabis use disorder will be excluded.
- Current threshold DSM-5 diagnosis of major depressive disorder, or presence of suicidal intention
- History of severe head trauma or other severe central nervous system disorder (e.g., dementia, Parkinson's disease, multiple sclerosis)
- Pregnancy or nursing infants
- Current use of medications or drugs known to interact with the CNS within at least four half-life post last intake
Key Trial Info
Start Date :
October 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2023
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04032587
Start Date
October 1 2019
End Date
June 30 2023
Last Update
January 26 2024
Active Locations (1)
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1
Dept. of Psychiatry, CCM, Charite Universitätsmedizin Berlin
Berlin, Germany, 10117