Status:
UNKNOWN
Stress and Brain Response Using MEG in PWS
Lead Sponsor:
The Hospital for Sick Children
Collaborating Sponsors:
Holland Bloorview Kids Rehabilitation Hospital
University of Western Ontario, Canada
Conditions:
Prader-Willi Syndrome
Eligibility:
All Genders
7-16 years
Brief Summary
Individuals with Prader-Willi Syndrome (PWS) have increased hunger and food seeking behaviour, as well as learning (cognitive) challenges. In addition, some patients with PW been shown to have low cor...
Detailed Description
Prader-Willi Syndrome (PWS) is characterized by hyperphagia, although the degree of food seeking can vary between individuals. This behaviour may be moderated by hormonal, neurocognitive, and psycholo...
Eligibility Criteria
Inclusion
- Genetically diagnosed PWS (study population)
- Adolescents matched for age, sex, and BMI-percentile (controls)
Exclusion
- Past or current history of alcoholism or consistent drug use
- Current untreated major psychiatric illness as defined by the DSM-V criteria
- Medications that decrease alertness (that cannot be held on the days of testing)
- History of recent major head trauma
- Current pregnancy
- Diagnosis of diabetes
- Current or recent smoker (i.e. \>2 cigarettes/week during past year)
- History of metal in body (shrapnel, metal slivers, unremovable metal adornments, clips, top braces, pacemaker)
- Use of glucocorticoid medications
Key Trial Info
Start Date :
May 30 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2024
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT04032639
Start Date
May 30 2019
End Date
May 1 2024
Last Update
September 13 2022
Active Locations (2)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G1X8
2
The Hospital for Sick Children
Toronto, Ontario, Canada