Status:
COMPLETED
Cerebral Blood Flow and tDCS
Lead Sponsor:
University of Iowa
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
With this study, the investigators will substantiate if regional cerebral blood flow (CBF) is affected by tDCS, assess the amount of CBF change in relation to different currents, and measure differenc...
Detailed Description
Aim 1: To determine the effects of different stimulation intensities on relative cerebral blood flow (rCBF). Currently, researchers use tDCS as an interventional modality to modulate the excitability...
Eligibility Criteria
Inclusion
- Confirmed diagnosis of multiple sclerosis by a neurologist
- No change in MS-specific medication (disease modification drugs) in the last three months
- Healthy enough to complete the protocol based on information obtained from a clinical exam and past medical history.
- An expanded disability status scale (EDSS) below 5.5
- Comprehension of the protocol as indicated by an ability to respond to questions about the study after reading the consent form.
- Able to use and be contacted by telephone
- Able to speak, read, and understand English, and complete a questionnaire in English
- Body mass index \<30 kg/m2
Exclusion
- A relapse of disease symptoms in the last three months
- History / presence of secondary conditions such as seizure disorders (or on medications known to lower seizure threshold), hydrocephalus, diabetes mellitus, or claustrophobia
- Alcohol dependence or abuse (\>2 drinks/day), or present history (last six months) of drug abuse
- History of significant traumatic brain injury or hydrocephalus
- Currently pregnant
- Recent hospitalization (within the last 3 months) or enforced bed rest/sedentary state
- Claustrophobia
- A subject will be excluded if he/she has a contraindication to Magnetic Resonance scanning, e.g., implanted metal clips or wires, which may concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field.
- Examples include:
- Aneurysm clip
- Implanted neural stimulator
- Implanted cardiac pacemaker or autodefibrillator
- Cochlear implant
- Ocular foreign body (e.g., metal shavings)
- Any implanted device (pumps, infusion devices, etc.)
- Shrapnel injuries
Key Trial Info
Start Date :
December 20 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 15 2020
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT04033133
Start Date
December 20 2019
End Date
August 15 2020
Last Update
September 28 2021
Active Locations (1)
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1
Department of Health and Human Physiology
Iowa City, Iowa, United States, 52242