Status:
UNKNOWN
Early rhBNP on Myocardial Remodeling and Reperfusion in Patients With STEMI
Lead Sponsor:
RenJi Hospital
Collaborating Sponsors:
Shanghai 6th People's Hospital
Shanghai Minhang Central Hospital
Conditions:
ST Segment Elevated Myocardial Infarction
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
The study intends to evaluate the efficacy of early rhBNP on myocardial remodeling and reperfusion in patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention
Detailed Description
As prospectively observational study，it brings anterior acute myocardial infarct patients from 2018 JAN. to 2019 JAN, whose predefined time between symptom onset and percutaneous is not more than 12 h...
Eligibility Criteria
Inclusion
- Patients are eligible for enrollment if they are suspected as anterior myocardial infarct (anterior myocardial infarct is defined as persistent chest pain for 30 mins at least, with ST-segment elevation of at least 0.2 mV in two or more contiguous precordial leads) within 12 hours after onsets of symptom, and no contraindication for rhBNP. The coronary angiography (CAG) proves left anterior descending (LAD) as culprit vessel, which was totally or nearly occlusion with TIMI 0-1 grade and resulted in TIMI 3 grade after PCI.
- Exclusive criteria:
- Killips grade III-IV.
- unstable hemodynamic; with A-V block or atrial fibrillation;
- Contraindication of magnetic resonance, such as history of metal, ICD or paceman implant;
- history of myocardial infarct;
- pregnancy or breeding;
- combined with other serious diseases: severe renal dysfunction (creatinine clearance\<30ml/min;), liver failure, neutropenia, thrombocytopenia, acute pancreatitis；
- life expectancy≤12 months
Exclusion
Key Trial Info
Start Date :
June 19 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2023
Estimated Enrollment :
352 Patients enrolled
Trial Details
Trial ID
NCT04033861
Start Date
June 19 2019
End Date
December 1 2023
Last Update
June 1 2023
Active Locations (1)
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1
Ren Ji Hospital Afflited to School of Medicine, Shanghai Jiao Tong University
Shanghai, China